Triffy asked me to post here because he felt awkward listing so many. So here we go...
Ansem Retort (http://www.ansemretort.org/mainpage.php)
Aww man, why is my list alphabetical. I don't want this first. :( Oh well, it's a sprite comic that I used to love but don't... like as much anymore. Either my sense of humour changed or its did or both. Who knows.
Awkward Zombie (http://www.awkwardzombie.com/index.php)
These can be a bit hit or miss for me, but mostly hits. I love the art.
Brawl in the Family (http://www.brawlinthefamily.com/)
Haven't really been as interested in this lately but it has a lot of really good comics. The artist has a lot of neat ideas.
This one is really weird. XD; The comics are strange so you have to have a bit of an odd sense of humour to like them.
Candi - A College Story (http://www.candicomics.com/)
I only read this one a few weeks ago because I was procrastinating on studying (like I am doing this very moment) and I was pleasantly surprised.
Mostly just keep up with this because I love the artist so much.
Doesn't update much. Went almost a year with nothing but creator has updated a few times in the last few weeks? Yay?
Flaky Pastry (http://flakypastry.runningwithpencils.com/index.php)
Sort of a fantasy mixed with sci-fi sort of thing? I think? I dunno. It's pretty good.
Garfield Minus Garfield (http://garfieldminusgarfield.net/)
...title says it all, really. I don't read the original comic (it doesn't... fit my sense of humour at all? idk) but this is so quirky and out there that I love it. XD
Goodbye Chains (http://www.goodbyechains.com/)
GAY COWBOYS. Or a gay one. Or something. idk. I lost the plot ages ago. I need to reread this since I've only been skimming for ages. XD
A lot of them don't make sense. They are awesome.
Hark, A Vagrant! (http://www.harkavagrant.com/index.php)
Mostly touches on literature and history but there's something for everyone. I love this artist and her style.
Heart Gold, Soul Silver Adventures (http://heartgoldsoulsilveradventures.smackjeeves.com/)
DEAD. ;_; But still a great read. I check it from time to time hoping there'll be an update but I'm too much of an optimist.
Hipster Hitler (http://hipsterhitler.com/)
Hitler as a hipster. I only added this to my list this week. XD;
Kind of like Surviving the World (below). Updates with graphs. :)
Manly Guys Doing Manly Things (http://thepunchlineismachismo.com/)
Was introduced to this by Kotaku. It's pretty good!
Menage à 3
...as the title suggests, this one isn't worksafe at all (but not overly explicit) but it's done by one of my favourite artists (Giselle :D) and it's hilarious.
Namir Deiter (http://namirdeiter.com/)
A friend submitted fanart for this yeaaaars ago and it was my introduction to webcomics. I kind of keep up with it mostly out of loyalty. o_O
Penny and Aggie (http://www.pennyandaggie.com/index.php)
The first comic I stumbled upon with Gisele as the artist (does Menage à Trois). I really liked it early on but now it's gotten silly and hard to follow. :s I don't want to attribute that to the new artist but I don't think he works well with the writer... idk.
Penny Arcade (http://www.penny-arcade.com/)
Nerd staple. Not much more to say. Sometimes the news updates are funnier than the comics.
Pictures for Sad Children (http://picturesforsadchildren.com/index.php)
I don't know anyone else who likes this but I discovered it last year and I love it. ._. Dunno how to describe it though, lol.
The Phoenix Requiem (http://requiem.seraph-inn.com/)
EVERYONE GO READ THIS. The art is gorgeous and the story is intriguing. It's just amazing, and updates a couple pages at a time, which is nice.
You Say It First (http://www.soapylemon.com/)
Only picked this one up because it overlapped with Namir Deiter once. :s I really only skim it everyday now...
Surviving the World (http://survivingtheworld.net/)
I recommend this to everyone. It's by a university prof & it's not a typical webcomic but it's still brilliant.
'Nother nerd staple.
Did not link to the ones that commonly have a bit of nudity or sexual jokes. You can google those for yourself if you want. Am also currently flipping through the history of SMBC. And I have about 6 more bookmarked that I've been rec'd but haven't had time to sit down and read anything from them yet. And I also read C&H sometimes (only when Kris posts his stuff on deviantART... I don't much care for the other artists).
I know I'm probably missing a bunch. ;_;
And augggh totally adding a bunch of the ones from this thread to my "potentials" list... XD