thought so.
Whever you go into the map, the box, or if you're in the middle of a story event/flashback, I disable the hotkeys, the re-enable them once that event is done.
For some reason, I misprogrammed something, so the hotkeys remained disabled. Going into the box disabled the hotkeys, then exiting the box would reenable them.
Ok... firstly, If you're like me, you use the numpad(right side of KB) so you might have accidently disabled numlock.
if that doesn't work... try these and post me the results.
1- Press all top number keys(1-0)
2- Press all numpad keys (0-9)
3- Try use the bike(make sure you're outside)
Now, go to the pokecenter, and enter the pokebox. then exit it.