ROM's don't have INI files in them, an INI file is the file that comes with the program that is used to configure the program to the ROM you are opening.
Check a few things...
Right click the ROM, and click Properties
If "Read Only" has a check mark next to it, un-check it.
Open the ROM in RHEA, and makes sure the rom has the correct header. (An ENGLISH Fire Red version is BPRE for instance)
You can also do that in a HEX Editor of your choice.
Finally, try re-downloading the program, a file or 2 may not have downloaded correctly, or were extracted from the ZIP file incorrectly.
Post back results here...