Of course, I'd love to see Kanto remade in 3D (X/Y style, or an even better one), but it's time for Hoenn to be remade. I've always been down on Ruby/Sapphire/Emerald, but Hoenn was an interesting region.
I suppose another Kanto remake can wait until the Pokemon series has moved to completely 3D environments. Which by that I mean landscapes designed like they're for a 3D world and not for a 2D world. Like when we move towards Ocarina of Time, away from Phantom Hourglass speaking in terms of Zelda. It'd be interesting to see Kanto reimagined in a 3D format.