It will also be remembered because for the first time, our longstanding relationship with Pokemon, that we had since the old days, is actually being questioned in the Form of N and Team Plasma and I'm sure many people had to pause and at least consider what they were saying.
Some might even have gone further and actually asked themselves some questions like:
What does it mean to be a Pokemon Trainer?
What should the relationship between Pokemon and said Trainers be?
Are we oppressing them by keeping them in Pokeballs?
So in terms of making us players contemplate and question the status quo like that, I don't think any other Pokemon game has had such an impact on us so far.
And it will probably be remembered as the first Pokemon Game that seems to be set outside Japan's four main Islands.