The plane was arriving from Seoul, South Korea, and apparently landed just short of the runway and struck a seawall:
Asiana Airlines Flight 214 was carrying more than 300 people when it crashed at San Francicso International Airport, tore off its tail and burst into flames.
Two people were reported dead, said San Francisco Fire Chief Joanne Hayes-White.
She described it as a "fluid situation" and that "not everyone has yet to be accounted for." She initially said that "upwards of 60 people were unaccounted for," but San Francisco Mayor Edwin Lee later said all the passengers had been unaccounted for.
The injured were being care for at several hospitals and at least 22 were in critical condition.
The flight originated in Shanghai, China, and had a stopover in Seoul, South Korea. It was carrying 291 passengers, including an infant, plus at least 16 crew members, according to the airline. An Asiana Airlines official in Seoul told ABC News that 141 Chinese, 77 South Koreans and 61 U.S. citizens were on board.
Thoughts and prayers to the injured, and R.I.P. to the two who perished.