Spam really irritates me. Especially when it's on a forum like this or a facebook group or something. It's just plain rude. It's kinda like walking into a party where people are all enjoying themselves and are really getting into a discussion on something and then someone who you kindly invited interrupting and screaming about how amazing their new phone or mail order bride is.
Nobody would ever do that in real life, and if they did they'd probably get their head kicked in eventually, so I don't see why some people think it's acceptable to do something like that online.
Overall I'm glad that I get to clean up the spam in this section. It makes me feel better knowing it's gone as soon as I see it. In other sections I try to just report it and move on.
"I am confident that if anyone actually penetrates our facades, even the most perceptive would still be fundamentally unprepared for the truth of House Dimir."
What irritates me is that there are many legitimate comments on YouTube marked as spam just because the person's opinion is unpopular.
With actual spam — just report and move on, or ignore it. Chain mails are a bit annoying due to the space they take up, but there's nothing one can do about it.
I am not very easily irritated by spam at first, but if I get mass amounts of spam from either the same person/group/organization/etc over time, or a whole mass of spam at once, that is when I can be a little angry.