My all-time favorite quote, the one I will always remember:
"Did I ever tell you the definition of insanity?"
Vaas' most famous quote. The passion in Vaas' voice is amazing when he speaks this, there is real meaning behind it. If you have watched the cutscene in which he says this quote, it all links in to the game so well - what he says makes you think and it's almost as if Vaas is interacting with you.
Nagakura Shinpachi: If you're big enough badass, everybody'll be like, "Damn, better not start sh*t with him, that'd be a bad idea." So nobody starts fights, and that means no wars! (Hakuouki - Demon of the Fleeting Blossom)
Location: In your pantry, eatin' your delicious cake.
I'll jump on the Portal 2 bandwagon with quite literally everything said by GLaDOS, Cave Johnson, Wheatley, the personality cores, and Chell.
Originally Posted by GLaDOS
Well done. Here come the test results: "You are a horrible person." That's what it says: a horrible person. We weren't even testing for that.
Originally Posted by Wheatley
Most test subjects do experience some, uh, cognitive deterioration after a few months in suspension. Now, you've been under for … quite a bit longer, and it's not out of the question that you might have a very minor case of serious brain damage. But don't be alarmed, all right? Although, if you do feel alarm, try to hold onto that feeling, because that is the proper reaction to being told you have brain damage.
Originally Posted by Cave Johnson
This next test may involve trace amounts of time travel. So, word of advice: If you meet yourself on the testing track, don't make eye contact. Lab boys tell me that'll wipe out time. Entirely. Forward and backward! So do both of yourselves a favor and just let that handsome devil go about his business.
Originally Posted by Various Personality Cores
I'll tell ya, it's times like this I wish I had a waist so I could wear all my black belts. Yeah, I'm a black belt. In pretty much everything. Karate. Larate. Jiu Jitsu. Kick punching. Belt making. Taekwondo… Bedroom.
In Victorian England, a commoner was not allowed to look directly at the Queen, due to a belief at the time that the poor had the ability to steal thoughts. Science now believes that less than 4% of poor people are able to do this.
"Do you remember my super-cool Rattata? My Rattata is different from regular Rattata. It's like my Rattata is in the top percentage of Rattata. Do you know what I'm saying?"
I don't have one particular favorite, but reading the above, it reminded me that Joker from Mass Effect did have quite a few I can remember (from ME2, at least).
"Why can't we go to war against a fuzzy planet? A dangerous one, but still fuzzy."
"What I can't stand about deep space is radio stations from two years ago. My gosh, we were idiots."
"There's another alien aboard, commander. Thanks... why couldn't you just go collect coins or plates or something?"