If is a game with fakemon, I would simply say Pokémon Vega. Normally, I don't really enjoy with fakemons in a whole Pokédex, but putting a small nummer of fakemons like in Ruby Destiny is okay.
But Vega is very different. Most of the fakemon looks nice, I liked the starters (especially the grass starters, they are cute) and the legendaries (they look majestic). Even it's Japenese, I have enjoyed the story and the many twists. The music was very good and fits the atmosphere und the region was really snowy. Team Dark Hole (D. H. for short) is a cool villain team and have very good battle themes. Some of the puzzles are, however, very difficult.
The same is with the predecssors and the successors, but I'm not thinking playing Altair/Sirius. I have tried Procyon/Deneb and they have a even better tileset. But again the battles are very difficult, so this ones are a worthly challenge.
When it comes to story line and event, I think Light Platinum and Victory Fire are the Best. Specially Victory Fire as it has Mega-Evolution in it. Besides those, Pokemon Ash Gray, Pokemon Shiny Gold or Pokemon Liquid Crystal and Pokemon Glazed version are pretty awesome hacks.