Definitely not. There's far too much potential for world-building with regions based on the many real world countries the franchise has yet to adapt, entire types that have yet to be introduced (Light, Wood, Sound, even Celestial for the likes of Deoxys), and there's been some fantastic improvements lately, what with the creation of Pokémon Bank being very simple, revolutionary compared to the old transfer system, and future-compatible.
I do think that some big changes are in order: removal of the Grass-Fire-Water trio at the beginning of each game, no longer beginning your journey with the original goal of completing the Pokédex, a cross-region that doesn't have the 8 Gym Leaders system, stuff like that. Generation 6 introduced few Pokémon, but they were fantastic designs with a simplicity that reflects Generation 1's charm. If that minimal trend continues, it will be great. Adding new evolutions to existing Pokémon would be good, too. Even different, seemingly unconnected Pokémon could share new pre-evolutions, which would be interesting. Hitmonlee and Hotmonchan were originally unconnected until Tyrogue was revealed to be their shared predecessor, which I found really neat.