What is Girl Genius? Girl Genius is a webcomic following the adventures of Translyvanian Polygnostic University (TPU) student, Agatha Clay.
...for all of two volumes.
Then, MAD SCIENCE comes into play, and the series gets awesome, with a family of mad scientists that kept Europa in their iron grip for centuries, the new Empire that has since risen in their absence, and the really, really annoyed heir who's had it with everyone's incompetence.
Though the series has been going for nine years (!!!), I managed to catch up to it after about two weeks of reading it on the side. Once you start, you can never stop.
Now, go get cracking with the SCIENCE!
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"I don't find my name tasteful next to Shanghai Alice."