eh...Tentai Senshi Sunred, or Astro Fighter Sunred is one of the newer ones that has comedic value. Each episode is only 13 minutes so it's good if you have other things to do and don't want to spend too much time anime-wise.
Lucky Star is also a popular choice, but they have a tendency of dragging on some of the scenes, although very fun to watch
Seto no Hanayome is also a pretty good choice, but the rating may be pretty borderline
Hidamari Sketch is also a really good choice comedy-wise, though it's comedy is a lot more subtle than the rest on this list
oh well what i meant by that was like: something funny,sorta happy,not badly rated (meaning like tv MA or 14, cause most of the shows im explaining are not tv 14 or MA)and not really depressing
ok?
eh...not sure what you mean, but mostly the reason i'm asking you to be more specific is first, that i haven't seen invader zim due to never having cable until a few years ago, and second, because most comedies in anime are mostly kinda like talk shows and the others are more stories that squeeze in comedy every once in a while
there are obviously derivations, but it gives me a much easier time to think that way