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Old January 31st, 2011 (7:03 PM).
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Kirbychu Kirbychu is offline
Join Date: Jun 2009
Location: Oregon
Age: 21
Nature: Naive
Posts: 2,346
Actually, every single member of the original Kanto Elite 4 has appeared in the anime at one point. Ash has actually battled (and lost) against Lorelei (Prima) and Agatha. It has been hinted that when a trainer wins their respective region's Pokemon League, they can participate in the Elite Four Challenge, fighting the four members of that region's Elite Four, and then possibly the Champion as well.