It's hard to imagine Pokémon going to be having up to 1000+ different types of Pokémon.. Of course there are spin-offs as well and technology is always advancing thus letting the company make advanced and better games than the old ones. I'm just not sure if anything actually new will come to the franchise other than the games.
They should make some Pokémon vs Digimon game like how LEVEL 5/Professor Layton Vs. CAPCOM/Phoenix Wright is coming out. awesome crossover.