I'd say it's sort of tough to predict what route they'll take or will not when it comes to this, but online, there seemed to have been a good portion of support behind them putting-together a region based off Canada by fans, and I feel it'd be kind of interesting to see how they go about taking things if they do decide on it at some point in future.
Personally, though, what I would like to see is a location inspired by some place such as India. They have yet to explore that part of world in terms of Pokémon regions, and I believe it would give us some chance to take a breath of air, so to speak. I know I'd definitely enjoy having an adventure through it.
India is generally a very populated area if I'm not wrong, and if they create a region after the country, in some of its towns, cities, and routes, I suppose we could expect there to be more NPCs than normal, haha. Also, since India is surrounded by hot weather most of the time, I'd imagine this location to be occupied by various ground, rock, fire, and grass Pokémon (as they tend to flourish under these kind of climates).