My first thought was Touhou Vampires Flandre Scarlet and Remilia Scarler, and the Touhou Werewolf Imaizumi. Disagree, Flandre was the best in the world!
Um? The real one? But I don't think vampires and werewolves were real creatures, even I don't know how the real vampires and werewolves look like. So I just say I don't know here.
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It's more and more difficult to think of a new statements here if you've played this game for a long time.
By 'real' I meant the ones from myth and legend. I was also insulting the Twilight series.