I'm not going to lie, I'm really uncomfortable with my gender from all standpoints, biological or otherwise.
The main reason to it is that a part of my brain is always craving for sex, & it makes me see myself as a male prostitute. Also, since I've got no plans on having children, my reproductive organs are useless to me. I'd love to be able to get rid of my reproductive organs, but it turns out that I can't, as they're a source of hormones that are crucial to my well-being (at least that's what I think.)
Earlier in my life, I would've loved to be a girl instead of a guy, but with the knowledge that it won't be any better if I was either gender, it has led me to dislike being a human altogether. I'd much rather be something that doesn't have any need for sexual reproduction. But alas, this is a burden that I have to bear until death...
Just thinking about this gets me more & more frustrated...!