Yes.
But the most important things are:
1. Experience (aka, at least have successfully Published 1 or more games on any Platform, a list is more helpful).
2. Secure Business Location (at least a separate room in your house with a lockable door is good enough).
You also need to make sure you're not involved with any (ROM) Hacking in any possible form, including playing them.
When Registering, you'll see the whole NDA on the form, but before Registering, I would recommend you to speak to Nintendo of Europe (if in Europe or Australia), or Nintendo of America (if in North-America, South-America, or Middle-East) by Phone.