I'd have to rewatch the entire first part of the anime for some. However, I'd make a point of finding areas not originally included in Kanto and seeing if you can somehow add them to the standard Kanto map and storyline. "Hypno's Naptime" is a perfect example with HopHopHop Town, and it would show great scripting skills to have kids hanging around the garden thinking they're Pokémon; you find out about it at the Pokémon Center when you arrive in town and can't proceed without it (perhaps because one parent is blocking the only exit to the town on the other side). I've always wanted to do an anime-based version of Kanto, myself. ;)