With me, it's not so much I want to honor the region I'm writing about, it's more like if I have an idea for the region. For example, with Unova, I can use the Pokedex entries for Cobalion, Verizion, and Terrakon for an idea that I was already tossing around. So I just combined them together. So when I say that I don't have plans for a B2/W2-based fic, it's because Reshiram's formes don't give me any ideas.
If the three Unova legendary Pokemon I plan on using were in another region, I'd write that region. But they're in Unova, so Unova it is.