Mass Effect 3 - I finally got into Mass Effect last year and I'm playing Mass Effect 2 right now. I think I can safely say that ME is right up there with Assassin's Creed as my favorite new franchises this gen. I'm definitely looking forward to how Shepard's story wraps up...even if I'm not done with ME2 yet. I doubt I buy this on release since I have plenty else to beat and the next game on my list comes out just around the same time, but it's definitely a to-play this year.
Tales of Graces f - I've waited a long time for Tales of Graces to get localized, and I haven't played a Tales game since Vesperia back in 2008. Plus, I want to support future Tales games getting localized. So I'm definitely buying this on release...which means ME3 might get relegated to a "down the line" buy.
Xenoblade Chronicles - I almost imported this last fall, but I'm glad I held back since Nintendo finally announced a North American release. I have a $75 GameStop gift card, and $50 of it is set aside just for this game. I've heard nothing but good things about it: how it's a breath of fresh air and revitalizes the JRPG genre. So I'm really looking forward to finally playing it for myself.
I guess I'm looking forward to KH3D too, but I'm honestly just sick of handheld KH spinoff-ish games. Birth by Sleep was great, but I'm ready for a full HD console game.