When you bring up topics of gender, I think it's common that people want to make sure the sex/gender differences are brought up, is all. It doesn't have to get serious, but it's just something I think Pala and Universe wanted to note because of the way you worded yourself, is all. Nothing ill, but I think calling it out and bringing it up is only going to dig that topic deeper. I'm not going to go further on it, though; just an observation.
Anyway, I usually pick for aesthetics. Typically has nothing to do with gender, pronouns, or what have you. Not in my case, anyway. But I know that some people like the representation and being able to choose is nice, especially for those that might have gender issues personally and a video game might be their only outlet to express that (ex. someone that identifies female, but isn't able to present that way in person can enjoy being able to play as a female in a game and not face consequences for it like they likely would in person).
Hopefully this makes some bit of sense.