I used the Mew glitch once, but the cart essentially became unusable shortly thereafter, and I've always been a little wary of it since. I have a feeling that the problem with the cart might have been caused by something other than the Mew glitch, but I don't know, so I tend to avoid doing it (or other glitches that actually screw up your save file) on my physical cartridges. But it was a lot of fun to do, and it was neat to find Mew after all those years. I haven't decided whether I'll try to do it on the VC release or not (assuming the glitch is still there).
I did obtain a Mew from a friend of a friend to complete my Pokedex in Gold, but I have a feeling it was hacked. No way to prove it one way or the other, though; the file is long gone.
(On a somewhat unrelated note, the cartridge issue was with Blue, and it would freeze every time I tried to display a text box or do anything else. I couldn't start a new game, either [it would freeze on the Oak screen and make a Gastly type cry followed by other noise]. I finally found a reference to a similar issue several years after it happened, but I still haven't been clear about what caused it [just bad luck with the cartridge wearing out? Something else?], and all of my other games are fine. Has anyone else here had something similar happen to a game?)