I'd like to see Cheren being in the E4, and Bianca being a Gym Leader, and you challenge Hilda/Hilbert at the end like Red. Alder retires, and a character from the original B/W is Champion.
Seven Sages/Shadow Triad hopefully have a large role, I would love to challenge them!
Anville Town and the Battle Subway could play a role in going to new places. (Maybe places in Unova that were not in B/W?) Or Skyla's airplane could take you somewhere.
I can't really see N returning to Unova, he had his role in B/W, and now he's off trying to liberate Pokemon in other regions.
Seven Sages/Shadow Triad hopefully have a large role, I would love to challenge them!
Anville Town and the Battle Subway could play a role in going to new places. (Maybe places in Unova that were not in B/W?) Or Skyla's airplane could take you somewhere.
I can't really see N returning to Unova, he had his role in B/W, and now he's off trying to liberate Pokemon in other regions.