I use Panda Cloud antivirus currently,and I'd remember it saved my desktop,the situation goes like this.I borrow my friend DVD,it contents of Virus,I don't install any anti-ware in my desktop that time,so when I run the DVD,my computer automatically shut down.When I restart,I feel my CPU run slower than before (lag).I don't have much savings that time,so I left it there until I find a way to solve the problem.About two years later,someone suggest me to use Panda Cloud.So I back home and run my CPU again,it's getting worst (you can't even imagine that how slow it is) ,but nothing to worry,I got the solution and I try it.Yes,it neutralizes all the virus inside,I remember it has thousand of weak virus inside (luckily it haven't getting stronger).After that,my CPU go back normal until now...
Maybe you can't believe what I'm talking about,you can try it on your own,maybe you will understand.I use the free version of Panda Cloud (it has premium version which offer more features) ,it works fine for me,it designs simple,it won't keep popping-up.
In my opinion,Panda Cloud is the best antivirus ever :)