After being fuzzy memory-wise for awhile, my Crystal finally died in mid-2007. This was after I had gotten Pearl, but before I had gotten any of the other DS ones. Crystal is the only GBC game I've ever owned. Yes, the last time I played Crystal was after the first time I played Pearl, but I didn't complete Crystal in that small timeframe. So, no.
It does sound a little aggravating, though. I am continually frustrated while playing Yellow (which is for GB, not GBC) because of not being able to use the Bicycle, or use HM moves on objects, at the push of a single button. Watching the severely-dated graphics can also be a little cumbersome.