I saw it! It's great!
There is a lot of video game nodding (err, references), but I went with my friend who's probably never played a video game in her life and she really enjoyed it. The film does have a lot of game stuff on the surface, but at its heart it really is more emotional and character based. The humor and dialogue works really well because it's just straightforward well-crafted and not reliant on any knowledge of games, although that does help you enjoy all the things in the background. The movie has everything in it that you'd need to know about games to follow along.
Visually it's not quite as stunning as recent Pixar movies, but it's certainly very close. Better than your average Dreamworks animation. The music was fantastic! I've already ordered the soundtrack. I don't want to get into spoilers, but it's more than just a romp in CGI-Land with quirky characters. The story is well thought out and everything in the movie just fits.
Definitely go see it.