Well, I don't really watch the anime anymore - or I don't go out of my way to - so I don't get any comments if I happen to be watching it when it's on TV; we usually have the kid's channels on in the morning, and Pokemon is on, so it's just on because it's on.
My parents are both aware that I play the Pokemon games, and when they see the adverts on TV, they'll actually ask me if I have that version yet, whether or not I intend on buying it or, if it's close to my birthday or Christmas, whether or not I'd like them to buy it for me. Whilst my parents disapprove of a lot of things I do, thankfully they're content to leave me to my hobbies. I like what I like, and when both of them like things which would be considered far more "childish" by conventional standards, if they did bring it up, I'd have more than sufficient ammunition to defeat their argument entirely.
My mother's reaction is actually usually "which one am I buying?" because we've been playing them together since the third generation; she'll get the opposite of whichever version I'm getting, so we can trade between ourselves, and because she enjoys it almost as much as I do; I got her hooked on Red after I got Yellow, and since then she's been playing them, so she's been a fan for almost as long as I have. In the case of the spinoffs like the Ranger series, she'll wait for me to finish playing it and then pick it up herself, and usually put more hours into it. My Mystery Dungeon Blue file racked up about sixty hours, and hers was three-hundred and twenty seven hours! xD