The region itself does not have any influence on what the Pokémon will look like. It may have influence on different forms, such as Shellos in Sinnoh; however they do not play any effect on what the Pokémon itself will turn out to be. The Isshu region itself is more advanced in technology, if any part of this is to influence the design of Pokémon (which I think will occur) will be minor. I don't think every Pokémon will be based on machines; they'll still be originated majorly from real life animals. I wouldn't mind a half-robotic, steel type Pokémon though. I think that will be pretty cool as long as it isn't overdone.
As for the truck idea. Yeah, I don't see that happening. XD; Funny to think about though.
As for the truck idea. Yeah, I don't see that happening. XD; Funny to think about though.