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Check out Unity. It was first developed for the mac platform and only released for windows last month.
It's amazing. I'm using it in college at the moment.
The only down side is, it's dear. Like really dear (well if you get a full licence, but you can develop for Wii and iphone then). You do get a 30 day trial. I'd check it out.
In more common used stuff. I'm sure Sphere has a mac OS release.