The opening sequence starts and the screen fades out black, after you click "New Game", into a Pokemon lab. The screen zooms into a professor. "Hi, you must be new to Isshu. What's your name?" The trainer screen comes up where you choose your name. "Welcome to the world of Pokemon, you will encounter . . ." a trainer runs in, "Professor Willow, come quickly, Mallack has escaped from your garden." "I'll save the introductions for later, help me find my Mallack - it's a duck type creature, you'll know when you see it. Pick a Pokemon, either Pokabu, Tsutaaja or Mijumaru. It will help you find Mallack if you turn around and talk to it every few steps. If it can pick up the scent of Mallack, it will let you know." You then pick a Pokemon and walk over to the professor. He guides you outside, into an open field. You see wild birds, dogs and rats, which you haven't seen before - there are 6, (similar to Pidgey, Poochyena and Pikachu.) All wild Pokemon in this area are field Pokemon, as they're professor Willow's. When you walk close to one, professor Willow calls you back. "My Pokemon aren't behaving normally, you'll have to fight them in order for them to calm down." You walk over to them and fight them one by one. During that time, the other trainer runs back with a duck. "-insert trainer name- come back here, my assistant has found my Pokemon!"
Inside the lab, the professor says to you "Hmm, you appear to have gotten quite close to your Pokemon. Would you mind looking after it for a while? I need to go to the next town to run a few errands, but I'll be back soon. While I'm gone, can you look after my lab?" You agree and the professor runs out. Nothing happens until you go out into the field. The professors Pokemon that was found earlier starts evolving , as well as the other Pokemon. The assistant runs over to you and says "They appear to be evolving. This was not expected. Can you go to the next town and find the professor for me?" This is when you leave to go to the next town, aka begin your journey.