I'm pretty sure that since Black 2 and White 2 are going to have a LOT of version differences again, like Black & White 1, that the leader for Opelucid Gym will depend on the version again as well.
Like, if Iris is the leader of your version, the town has grown more agricultural: maybe vines growing up the sides of buildings, little windowsill gardens, some terracotta archways...
Or if Drayden is the leader of your version, the sidewalks are actually conveyor belts, there are lots of street lamps, cars & trucks moving overhead, a huge futuristic clock tower...
Also, I'm pretty sure there are only two gym paths that make any kind of sense:
Cheren - Homika - Burgh - Elesa - Clay - Skyla - Drayden/Iris - Shizui
Cheren - Homika - Burgh - Elesa - Clay - Skyla - Shizui - Drayden/Iris
The first one is a linear path. I'm pretty sure most people agree that Shizui seems to be located someplace in Eastern Unova, and since there's a clear path from the starting town all the way to Opelucid (and only 7 gyms currently visible), it could be that the Kyurem plot plays out after Gym 7. Only afterwards would we face Gym 8.
Now, path #2 is kinda interesting! If, after we beat Skyla, she lets us hitch a ride one her plane, maybe she'll fly us over to the new airport that's in Eastern Unova (you can see it on the map) and we'll face Shizui over there before the 8th Gym.