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OK, so far we have:
Bad controls
Bad/Cliche story
Stupid Antagonists
Sneaking around
License titles
Advertising
Loading times
What else... Ah! Difficulty. It's OK if there's something along the lines of an easy mode, but if it's just a single difficulty but it's MONSTROUSLY hard like Silver Surfer on the NES (lol AVGN), ragequits.
oh, yeah! that...However some games, like the Contra series require the hardness to make the game fun.
30
EDIT: Games that go though the whole game to point as a certain evil guy as the main Antagonists, then near the end of the game, switch to another Antagonists.