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4th Gen pokerus

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Not if it is in your box, if a Pokemon is in your party with PKRS and the time turns midnight (your DS does not have to be on), your Pokemon will lose PKRS. It will be "cured" and get a :| face. It will still get double EVs, but can't spread PKRS. To prevent this, keep a Pokemon with PKRS in your box because the boxes freeze time.
 
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