You have to patch the IPS file together with whatever game the ROM used for a base.
IE, if you're trying to play a game that's a hack of FireRed, then you'll have to download a FireRed ROM, and an IPS patcher to patch the two files. & If I'm not mistaken, there are .IPS patchers that will work a Mac OS. You might just have to Google for 'em.
Past that.. it's currently not my place to close this, so.. xD; the rest is up to Hiidoran.