I'd like to note 2 things I found early in the game.
1: The girl's running sprite is bugged.
2: The girl's Bike sprite is unchanged.
Other than that, it seems good so far. I'm sure that will change soon though... I don't exactly go on the well traveled path of pokemon (And if I can finish Ash's Quest with this - albeit with massive SS abuse [That hack's HARD!] - then I can do it here.)
EDIT: The TV in Ash's room freezes the game if it is talked to after you go to sleep.
EDIT 2: After you name the rival, his face becomes red.
EDIT 3: If you switch in the first battle against Team Rocket (What? I had to protect my good pokemon, Death Row the level 10 Spearow!), the whole world goes to pot.
EDIT 4: Anytime I enter a city, the backround turns red. Same as Viridian Forest.
EDIT 5: Sorry, EVERYWHERE is red. Except the Route leading to the Elite Four. And I have to raise that freaking Pikachu to even have a shot at Brock.