Well, yes and no.
I don't use Photoshop to "make" my profile, I use CSS for that. Same with my signature, I use CSS to make it, but I edit standard photos of Pokemon (in Photoshop) to "fit" them into the code. Like.. my current signature has two pictures of Cherrim, those pictures I have edited to fit those perimeters, but I used CSS to make them work.
I have a list of CSS Color Hexs. So, I just mix and match certain things to collaborate with certain Pokemon. But, as you can see in the yellow parts of my profile, there is a slight fade to white, then back to yellow. This I have done manually in Photoshop, then inserted into my profile. So, I do it all manually, I don't just copy and paste anything into Photoshop and call it my profile. I use the same page they show you when you want to customize your profile.
So yeah. That's pretty much it. Having an alternate account helps though. ;D