The game opens to a boy sitting on the beach near Vermillion staring at the sun. This character is Red. Blue enters the scene and walks up to Red.
"Red, I'm ready to take you on again."
"......"
"Why aren't you saying anything? I want to battle you!"
"......"
"...Hmph! You'll regret this Red. Grandpa, can you find someone worthy enough to take on Red for me? It might finally break his silence."
Professor Oak walks onto the scene.
"I heard that Gold was moving to Johto, he sounds like a formidable opponent." "Well, he better be stro—"
"Professor, come quickly," a man said, as he walked on-screen. This man was Lt Surge.
"What is it?"
"Isshu... has exploded."
"Wha?! How did that happen?! I need to investigate."
"You can take one of my children."
"I don't know whether that's very safe..."
"Please, come on, maybe they can help you uncover the ruins of Isshu or something. You know that rumour? We've heard things about the rumour for a while now and they most likely are the cause."
The screen then fades black into the "Are you a Boy or Girl?" scene. You pick your name [Colour] and then your character is minimised as the screen goes back to the beach, where Blue, Red, Lt Surge and Professor Oak are standing. In this time, a plane has flown in to travel to Isshu.
"Wait, I forgot. Colour, you need to have at least 2 gym badges in order to use this plane due to Kanto's rules and regulations. You'll need a Pokemon in order to do this."