There's honestly problem if a deck revolves around "one strongest card" unless the whole strategy is to revolve around that one card, but that's extremely rare... Even Demise OTK technically does not consider Demise as the "strongest" one. Demise clears the field, but needs Advanced Ritual Art (card 2), which pitches the normal bugs for Doom Dozer (card 3), and both of them can be metamorphosised (card 4) into Cyber Twin Dragon for the real damage (card 5). Setting up obviously uses the searchers (card 6, 7, 8?) hehe...
God cards use the wrong color for all of them... not to mention, broken effects if we have to go according to anime. However, if we're really going by anime rules, then Obelisk is the only one remotely possible to be permitted... 3 tributes is hard, even if it's for something with trap/monster effect immunity, and one turn spell-effect. The major drawback is that Obelisk dies to a Cyber Dragon if Limiter Removal or shrink is facedown XD;