I have a few favorites from different series, so I'll just list them in order of favorite to least favorite. Art is included for those who don't know what they look like.
For Pokemon, I like Crys, Dawn, White, Leaf, & Sabrina. I just love their designs, and Sabrina isn't as evil as the manga and anime make her out to be, she's actually really nice.
For Kingdom Hearts, I like Aqua (Birth by Sleep) & Xion (358/2 Days). They are both pretty and kind Keyblade Wielders. Aqua is kind of like an older sister to Ven and Xion is a lonely girl who doesn't know her past.
For Final Fantasy, I like Terra Branford (VI), Rydia (IV), Tifa Lockhart (VII), and Oerba Yun Fang (XIII). Terra is sweet, but unsure of herself. Rydia is kind and have strong personalities. Tifa is a kind, but secretly shy, girl with an amazing physical ability. Fang is a strong and proud woman who protects her dearest friend.
For Legend of Zelda, I like Princess Zelda, especially her designs in Link to the Past (first two) and Twilight Princess (last one). Zelda is always a kind girl with a strong personality, as well as something of a tomboy according to some sources.
For MegaMan, I like Leviathan from MegaMan Zero. She's a strong girl with a somewhat twisted personality, but eventually she gives her life to save Zero and the people she's meant to protect from the twisted designs of Dr. Weil.
For Darkstalkers, I like Morrigan Aensland & Lilith. Despite their demonic appearances, they are not evil. They are more like a neutral party. Morrigan is a strange mixture of sexual, cute, and strong personality traits, while Lilith is both cute and a little deviant.
For Street Fighter, I like Sakura Kasugano & Chun-Li. Sakura is an average schoolgirl, but she taught herself versions of Ryu's fighting style and aspires to be as great as he is one day. Chun-Li is a Hong Kong detective who's father was killed by M. Bison. She dedicates herself to stopping him and eventually opens an orphanage.
For Bleach, I like Nelliel 'Nel' Tu Odelschwank. Nel has a dual personality. While she is fighting, she is serious, rarely speaks, and used devastatingly strong attacks. However, when she isn't fighting, she has a cute, almost child-like personality and loves to play games. She only fights if there is a reason, such as protecting someone.
For Sailor Moon, I like Michiru Kaioh, aka Sailor Neptune. Michiru is a stark contrast to her girlfriend, Haruka (Sailor Uranus). She is feminine and elegant, with an extraordinary skill with the violin.
and in Comic books, I like Psylocke (Betsy Braddock) and X-23 (Laura Kinney). Psylocke was born a British woman, but was eventually forcefully swapped into Ravange's Asian body. She has a variety of telekinetic powers and is greatly skilled with a Katana. X-23 is the female clone of Wolverine and Sarah Kinney. Like her 'father', she has 6 claws, however, unlike him, she has only two on each hand instead of three, with the other two on her feet (one on each). She led hard life since she was raised to be a killer, but she's slowly becoming more of a hero, although she still has an anti-social personality.