OH MY LORD, THANK YOU!!!!!!!!
I was starting to lose hope on all you people.
I can easily say hands down this is THE MOST depressing anime I have ever watched, and probably ever will watch. Ever. If you did not cry (on average) at least once per episode, I would be shocked if you were even human. I can say that I've cried on average about every episode or so (especially towards the ending). I'm also seeing tons and TONS of you listing "oh when Pikachu (almost) left." or "when L/Light/whoever died", but this. This just does not compare... not even close. It's just not..
I would seriously recommend this anime, especially for those who enjoy shows that are not for the faint of heart. Words cannot express how much I love this series... I'd put it up there with Elfen Lied, another great one (and one I've also cried watching), for sure. I can definitely say it's a favorite, and those are hard to come by these days, especially when most anime I watch I can't even finish because they aren't interesting enough to catch my attention for more than ten episodes.