I was playing Sacred (a RPG à la Diablo that probably no one here knows), and after some serious grinding (to a level where I could pretty much beat the final boss of the game, heh) I was rushing through the storyline with my awesome Battle Mage, until the game crashed at one autosave point, after 2 hours of not having saved (because I was distracted with a massive sidequest). I count that as a death.