A good question, indeed.
Talkin about the games: There's the possibilty the names Pokémon Black and Pokémon White won't make it outside Japan. Why? Well, some people think that the names are racist so... you know what Nintendo is making to the games (removing the slot-machines and replacing them with a sudoku-wannabe). Maybe they'll change them to some mineral names or something boring...
Talking about Pokémon: Well, we don't even know what animal they're based on...
This, sir, would be pure win.
Off Topic: Aww, Hitler's angry because he lost his gameboy D: