Well, I grew up with the anime, and it was quite a while before I shifted in and out of my anti-Pokemon phase (caused by Digimon) and actually played Sapphire. From FireRed to Emerald, with Platinum, HeartGold, and Gray following in the near future, the games have become a mainstay. They allow the player to get more immersed into the world of Pokemon than the other forms of media, and their quality (tends to) be superb. The anime gets a bit childish at times, but Best Wishes is slowly but steadily rectifying that problem.
However, the original series anime will always be a memorable classic to me, since that was my first-ever gate into the world of Pokemon. Right now, I prefer the games, followed by the anime. As successful as the TCG is, it seems a bit...superfluous to me as I've never fully interacted with it at all other than commercials and stuff (played with a relative's Pokemon cards when I was quite young), but the artwork that stems from it can be nice. I hardly keep up with Pokemon Special, but portions of it seem interesting. If I read Pokemon manga, it's probably to get an extra dosage of what the anime provides - a window into another Trainer's Pokemon journey.