Probably would, just because longevity doesn't really matter to me (but rather quality of life), and that there's only about a 10 out of 6 billion chance that someone I really care about will die. I know, selfish, but the person would die of a pretty quick death. They wouldn't even notice it, so it might even be a good thing in the sense that that person wouldn't have to suffer through a terminal illness or something.
Dunno what I'd wish for exactly. It'd be along the lines of knowing all languages, flying and being able to read minds. But I'd need time to really work out the details.