I'll one-up that and say Mega Man.
I'll avoid the obvious answers. As much as I love Uncharted, you seriously can't do much with the formula without a major overhaul. Instead of getting excited for Uncharted 4 all I thought was "really?" and just kept thinking about how it won't be as good as UC2 anyway. Also, I honestly think Little Big Planet should just die.
Halo as well. I do NOT like the way 343i is treating the franchise. Halo 4 was terrible. Halo 3 was the last good game (and god damn was it good) but the series was going seriously downhill afterwards. Just when you thought they hit rock bottom with Reach, they release Halo 4....yeah. Destiny looks pretty much like Halo with its combat evolved anyway, so us fans will get our fill. (excuse the pun, I couldn't help it.)
Resident Evil...I wouldn't put it here normally, since 5 wasn't bad and 6 was the only mediocre game, but after reading the whole collaboration with fashion magazines that Capcom is going for and how they just publicly stated they're aiming for teenagers as their target audience just screams NO.
I'm honestly also getting tired of 3D Zelda. The direction they're going for these days is off putting. Personally, I only liked OoT of the 3D entries (I actually liked Skyward Sword too, but only because of the awesome combat and dungeon design, everything else sucked), so I'm not particularly into the series. But I wouldn't want the series to die, just for the team to make maybe one more 2D Zeldas (Since ALBW was great) and apply what made them very good to the 3D series. Or basically, OoT2.
The only milked series I can think of that SHOULDN'T be put off is Mario. (Mainline Mario at least) NSMBU/NSLU is the best 2D Mario and 3D World is a serious contender for Game of the Year (as much as I don't really like it) the series is clearly still going strong.