I know someone with Asperger's Syndrome, yes. Unfortunately, he was raised by an, um, interesting, family, and is completely unbearable more than half the time. Instead of helping him, they've basically encouraged all the social negatives it brings.
The very first time I met him, he essentially told me that I was an idiot who didn't know anything about anything and that I was also an evil Satanist psychopath because I had an Eevee charm on my bag. I had known him for all of ten minutes when this happened.
Since that time, despite attempts to be nice and work with him for the theatre we both volunteer at, he has proceeded to insult, amongst other things: myself, my family, my friends, my upbringing, mine and my sister's competency, and all of our religions. (Which, for the record, are the same. So...?)
He's even caused little kids to cry; he's bragged around the crew about how he loved frightening all the kids in the show and how funny it was.
On a rare occasion, he's conversational and somewhat friendly towards me. I think now that he is older and has to work with more people who are less tolerant of him acting out, he is at least getting a little better. Thankfully, I know his family has a large part to do with it, but it doesn't make the experience any more pleasant. :/
That aside, the only time I can recall being around someone with autism was in gymnastics; one of the boys in the advanced class was an amazing gymnast, but incredibly sensitive to sound and had to wear thick headphones the entire time he was there. He was two levels above me, so we didn't speak much, though. Other than that, I have a lovely friend who I don't get to speak to often that carries some genes linked to autism (wording is fuzzy here), but that's about it.