Unova isn't a horrible name for the region. Personally, Isshu just rolls off the tongue a lot easier, and I'm used to regarding the new region as that. It won't take long to adjust though. It may not be the best region name, but it's not terrible either.
I like that it has multiple meanings to it, and it's not only the English copies getting a whole conversion from Isshu. To me, that's what caught me by surprise the most. The fact that they made a whole turn around from Isshu to Unova wasn't all expected.
Makes me curious though. If Unova was created by compiling more than one word together, and they did the same with the starters. I wonder if more of the translations in names will be words put together, than something all original. I know they've done this before in the past, but it seems to occur to me that they're doing it more so now.
Are they really running out of ideas? :x