I guess I haven't really been watching anything spectacularly original, mostly Code Geass on Adult Swim. :/
However, I'll comment on the Anime Blood +, since it was the last thing I watched all the way through, and even then, it was a while ago...
First of all, I couldn't wait for the English DVDs to come out, so I bought the Japanese DVD boxset. The first thing I noticed about the DVDs was that the main menu was very poorly done. Like... Just awful. In addition, the English subtitles (while appreciated) were terrible. They constantly used things like CBLY for "Chevalier" and other odd abbreviations... At times I had to rewind and figure out what they meant.
The show, however, was fantastic. At first I wasn't quite into it (when it aired on Adult Swim), but when it got towards the middle, I really liked how it picked up. Adult Swim was really slow on getting new episodes out, so that's when I bought the Japanese DVD boxset. The ending was fantastic, as well, but I won't spoil anything.
Oh yeah: *Gives a box of assorted sweets to digi*