To be honest, I don't have a preference when it comes to an antagonist because I killed all my antagonists off in my original novel. So, I don't have a specific lean. I'd say that my current fanfiction, which is almost finished, the main antagonist is the Tsaritsa but, she's not in the story a lot. I write her to be an extremely extra drama queen who acts like she owns her Fatui and they're her property.
& IL Dottore is another one in the story I would describe as an inhumane monster, I guess? It's hard to say.
It's kind of hard to pinpoint an antagonist or villain since my main character is with the antagonist organization against his will. So, most of the time, there really is none, just the main antagonist pulling the strings behind the scenes off page.